Asbestos and Its Toxicological Concern

Chemical Similarity and Threshold of Toxicological Concern

There are many national, regional and international programmes – either regulatory or voluntary – toassess the hazards or risks of chemical substances to humans and the environment. The first step inmaking a hazard assessment of a chemical is to ensure that there is adequate information on each of theendpoints. If adequate information is not available then additional data is nee...

Rehabilitation and Its Concern

The Threshold of Toxicological Concern (TTC) in risk assessment.

The Threshold of Toxicological Concern (TTC) is a level of human intake or exposure that is considered to be of negligible risk, despite the absence of chemical-specific toxicity data. The TTC approach is a form of risk characterisation in which uncertainties arising from the use of data on other compounds are balanced against the low level of exposure. The approach was initially developed by t...

Thresholds of Toxicological Concern - Setting a threshold for testing below which there is little concern.

Low dose, low risk; very low dose, no real risk. Setting a pragmatic threshold below which concerns become negligible is the purpose of thresholds of toxicological concern (TTC). The idea is that such threshold values do not need to be established for each and every chemical based on experimental data, but that by analyzing the distribution of lowest or no-effect doses of many chemicals, a TTC ...

Lipid Peroxidation and Its Toxicological Implications

Lipid peroxidation is a free radical oxidation of polyunsaturated fatty acids such as linoleic acid or arachidonic acid. This process has been related with various pathologies and disease status mainly because of the oxidation products formed during the process. The oxidation products include reactive aldehydes such as malondialdehyde and 4-hydroxynonenal. These reactive aldehydes can form addu...